Her work orchestrates transformations of natural resources, alongside extensive wide-ranging, interdisciplinary research into the landscapes where their exploitation and speculation take place. Through her work, she places together different epochs, regions and societies, examining political-economic, historical and cultural aspects.

Letelier explores commodity compounds, using their properties - such as electrical conductivity, crystallisation and living agency - to develop material poetical installations and objects. Her work experiments with chemical and physical transformation processes that produce the art work and its poesis beyond extractive and industrial forms of control.

Letelier obtained her BA from the Universidad Católica de Chile in 2000 and has participated in postgraduate programmes such as Goldrausch Künstlerinnenprojekt (Berlin) and as guest student at the Universität der Künste (Berlin).

Her work has been shown internationally in biennials, galleries, museums and institutions, among others: Screen City Biennial (Stavanger); Bienal Sur (Buenos Aires); El Museo de Los Sures (New York); Museo de la Solidaridad Salvador Allende (Santiago); Cini Foundation (Venice); Museum of Contemporary Art (Santiago); Centro Cultural Palacio de La Moneda (Santiago), Museo Nacional de Bellas Artes (Santiago) and Kommunale Galerie Charlottenburg (Berlin).